You are here: Home / Publications / Linding Lab, BRIC & DTU [2011-present] / Response to Comment on “Positive Selection of Tyrosine Loss in Metazoan Evolution”

Response to Comment on “Positive Selection of Tyrosine Loss in Metazoan Evolution”

Science 20 May 2011: Vol. 332 no. 6032 p. 917
Tan CS, Schoof EM*, Creixell P*, Pasculescu A, Lim WA, Pawson T, Bader GD, Linding R.

*: Equal Authorship

Science Response

Su et al. claim GC content variation can largely explain the observed tyrosine frequency variation independent of adaptive evolution of cell-signaling complexity. We found that GC content variation, in the absence of selection for amino acid changes, can only maximally account for 38% of the observed tyrosine frequency variation. We also uncovered other mechanisms acting to reduce tyrosine phosphorylation that further support our previous proposal.

 

[PDF]

[Supporting Information]

[Publisher]

[Pubmed - Awaiting Pubmed's new comment/response indexing]

Document Actions

Navigation
« July 2017 »
July
SuMoTuWeThFrSa
1
2345678
9101112131415
16171819202122
23242526272829
3031